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dc.contributor.authorCeinos, Rosa M.
dc.contributor.authorTorres, Eva
dc.contributor.authorChamorro, Ruben
dc.contributor.authorNovoa, Beatriz
dc.contributor.authorFigueras, Antonio
dc.contributor.authorRuane, N. M.
dc.contributor.authorRotllant, Josep
dc.date.accessioned2013-01-21T12:00:00Z
dc.date.available2013-01-21T12:00:00Z
dc.date.issued2012
dc.identifier.citationCeinos RM, Torres-Nuñez E, Chamorro R, Novoa B, Figueras A, Ruane NM, Rotllant J: Critical Role of the Matricellular Protein SPARC in Mediating Erythroid Progenitor Cell Development in Zebrafish. Cells Tissues Organs 2013;197:196-208 (DOI: 10.1159/000343291)en_GB
dc.identifier.issn1422-6405
dc.identifier.urihttp://hdl.handle.net/10793/846
dc.descriptionNOTICE: this is the author’s version of a work that was accepted for publication in Cells Tissues Organs. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. The Copyright for this material belongs to Karger. A definitive version was subsequently Cells Tissues Organs, [Issue 197, (November 2012)] (DOI: 10.1159/000343291), http://content.karger.com/ProdukteDB/produkte.asp?Doi=343291en_GB
dc.descriptionpeer-reviewed
dc.description.abstractSparc (Osteonectin) is a multifunctional matricellular glycoprotein expressed by many differentiated cells. Members of this family mediate cell-matrix interactions rather than acting as structural components of the extracellular matrix and therefore can influence many remodelling events, including haematopoiesis. We have investigated the role of sparc in embryonic haematopoiesis, using a morpholino antisense oligonucleotidebased knockdown approach. Knockdown of sparc function resulted in specific erythroid progenitor cell differentiation defects that were highlighted by changes in gene expression and morphology, which could be rescued by injection of sparc mRNA. Furthermore, a comparison of blood phenotypes of sparc and fgfs knockdowns with similar defects and the sparc rescue of fgf21 blood phenotype places sparc downstream of fgf21 in the genetic network regulating haematopoiesis in zebrafish. These results establish a role for an extracellular matrix protein (Sparc) as an important regulator of embryonic haematopoiesis during early development in zebrafish.en_GB
dc.language.isoenen_GB
dc.publisherKargeren_GB
dc.relation.ispartofseriesCells Tissues Organs;197
dc.subjectsparcen_GB
dc.subjectOsteonectinen_GB
dc.subjectECMen_GB
dc.subjecthaematopoiesisen_GB
dc.subjectgata 1en_GB
dc.subjectfgf21en_GB
dc.subjectZebrafishen_GB
dc.titleCritical Role of the Matricellular Protein SPARC in Mediating Erythroid Progenitor Cell Development in Zebrafishen_GB
dc.typeMonographen_GB
refterms.dateFOA2018-01-12T05:13:56Z


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