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Please use this identifier to cite or link to this item: http://hdl.handle.net/10793/419

Title: Combined oral toxicity of azaspiracid-1 and yessotoxin in female NMRI mice
Authors: Aasen, J A B
Espenes, A
Miles, C O
Samdal, I A
Hess, P
Aune, T
Keywords: Azaspiracid-1
AZA1
Yessotoxin
YTX
Marine algal toxins
Absorption
Pathology
Sublethal
NMRI
Mice
LC-MS/MS
oral toxicity
Issue Date: 2011
Publisher: Elsevier
Citation: John A.B. Aasen, Arild Espenes, Christopher O. Miles, Ingunn A. Samdal, Philipp Hess, Tore Aune, Combined oral toxicity of azaspiracid-1 and yessotoxin in female NMRI mice, Toxicon, Volume 57, Issue 6, May 2011, Pages 909-917, ISSN 0041-0101, DOI: 10.1016/j.toxicon.2011.03.014
Series/Report no.: Toxicon;57 (6)
Abstract: For many years, the presence of yessotoxins (YTXs) in shellfish has contributed to the outcome of the traditional mouse bioassay and has on many occasions caused closure of shellfisheries. Since YTXs do not appear to cause diarrhoea in man and exert low oral toxicity in animal experiments, it has been suggested that they should be removed from regulation. Before doing so, it is important to determine whether the oral toxicity of YTXs is enhanced when present together with shellfish toxins known to cause damage to the gastrointestinal tract. Consequently, mice were given high doses of YTX, at 1 or 5 mg/kg body weight, either alone or together with azaspiracid-1 (AZA1) at 200 μg/kg. The latter has been shown to induce damage to the small intestine at this level. The combined exposure caused no clinical effects, and no pathological changes were observed in internal organs. These results correspond well with the very low levels of YTX detected in internal organs by means of LCMS/MS and ELISA after dosing. Indeed, the very low absorption of YTX when given alone remained largely unchanged when YTX was administered in combination with AZA1. Thus, the oral toxicity of YTX is not enhanced in the presence of sub-lethal levels of AZA1.
Description: NOTICE: this is the author’s version of a work that was accepted for publication in Toixcon. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Toxicon, [Volume 57, Issue 6, May 2011] doi:10.1016/j.toxicon.2011.03.014 http://www.sciencedirect.com/science/article/pii/S0041010111001000
peer-reviewed
URI: http://hdl.handle.net/10793/419
http://dx.doi.org/10.1016/j.toxicon.2011.03.014
ISSN: 0041-0101
Appears in Collections:Peer Reviewed Scientific Papers

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